What is the difference: Dysport vs. Botox vs. Xeomin vs. Jeuveau?

While all four neurotoxins are similar in their make-up and function, they have slight differences in onsets. All neurotoxins take full effect at approximately 2 weeks. 

The formulation of Xeomin differs slightly from the others as it contains no additives and does not require refrigeration. They also vary slightly in the appearance of results. 

The effects of  Botox® (onabotulinumtoxinA) begin to take effect starting at three to five days after treatment. Xeomin® (incobotulinumtoxinA), can take even longer, with results becoming apparent between five to seven days. Dysport® (abobotulinumtoxina), is the option where results in the target areas will be seen most rapidly, with visible results within one to two days after treatment. Jeuveau® (prabotulinumtoxinA-xvfs), “New Tox” has effects beginning in two days. 

While both Jeuveau and Botox are made from botulinum toxin type A, the manufacturing processes and purification techniques used to create the products are slightly different. As a result, the proteins in Jeuveau are smaller and more uniform than those in Botox, which may result in a slightly quicker onset of action for Jeuveau.

Xeomin and Dysport treatment also have greater diffusion than Botox and Jeuveau, which allows them to reduce the appearance of wrinkles over a larger area such as the forehead. Botox is much more targeted and one of the most effective treatments for severe wrinkles in the glabellar lines. 

All four options are effective to all targeted areas. 

Which neurotoxin is best for me?

Botox®, Dysport®, Xeomin®, and Jeuveau® are all incredible choices and are effective at their mission: smoothing out wrinkles and rejuvenating your skin. The best neurotoxin for you is entirely dependent on your beauty goals, facial structure, age, and YOU

BOTOX®

• FDA Approval: The first neurotoxin to be approved by the FDA as a temporary aesthetic treatment to improve the appearance of frown lines between the eyebrows in April 2002. It has since been cleared to treat forehead lines and crow's feet, too (in addition to all its "off label" uses).

• The Skinny: Botox®, or onabotulinumtoxinA, is a product of the drugmaker Allergan, and it currently holds an estimated 80 percent of the BoNT-A injection market. With a molecular weight of 900 kDa, Allergan formulates botulinum toxin type A with protective proteins that a subset of patients may develop an antibody against over time, lessening the effectiveness of the treatment. 

  There is also a therapeutic version of product that can be used to treat medical conditions like migraines, excessive sweating, and eye spasms (to name a few).

• The Results: Botox® is effective but not permanent. It takes about three to five days post-treatment for the results to appear (though it can take up to two weeks for the final effect to be visible), and it lasts about three to four months in most patients. The longevity depends on everything from the way a patient's body metabolizes the product to the area being treated.

DYSPORT®

• FDA Approval: Dysport® was first approved to treat frown lines in April 2009, and, like Botox®, also has therapeutic uses to calm muscle spasticity.

• The Skinny: A product of Medicis Pharmaceutical, Dysport® (a.k.a. abobotulinumtoxinA) is slightly less potent than Botox® due to its molecular weight. While both have the same 150 kDa of BoNT-A at their core, the weight of the protective proteins in Dysport® are not uniform like those in Botox®. As a result, Dysport® has a higher rate of diffusion, which makes it ideal for treating larger areas (think: foreheads) — though more product may be needed to achieve results. Nonetheless, the cost is generally comparable to Botox®. Like Botox®, it is formulated with human albumin, and Dysport® also contains lactose and cow's milk protein — making it unsuitable for patients with milk allergies.

  The Results: While the effects of Dysport® may show up sooner (within 24 hours) than Botox®, some studies have shown that they may not last as long.  I find they both last about the same, but the shorter lifespan could make it a good choice for patients who are unsure about whether they will like the results of BoNT-A injections.

XEOMIN®

• FDA Approval: Jeuveau, owned by Evolus, received FDA clearance as a wrinkle treatment in 2019. The FDA clearance approved use to temporarily improve the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults. It’s focus is solely on the use for cosmetic purposes. 

• The Skinny: Jeuveau, also coined the name “Newtox,” is the new kid on the block. It contains the same active ingredient as Botox, and both are used to treat wrinkles. Essentially, It's the same ingredients, but a different recipe. Newtox has been proven to be safe,  takes about 15 minutes, requires no downtime, and produces results that last three to four months.

  - The Results: Results from Jeuveau® injections take 2-5 days to become visible and last a similar amount of time to Botox®, Dysport®, and Xeomin®, although the company Evolus, claims to last longer than the others - up to 4 months. 

  
  

BOTOX®

• Benefits: Good for treating all areas — especially small ones (think: crow's feet) 
• Onset: 3-5 days
• Results: 3-4 months
• Average Units: 20 for forehead treatment
• Drawbacks: Patients may develop antibody resistance over time

DYSPORT®

• Benefits: Good for last-minute treatments because of faster onset time; ideal for treating larger areas (i.e. the forehead) because of diffusion
• Onset: 24 hours-48 hours
• Results: 3-4 months
• Average Units: 50 units for forehead treatment, equal to 25 Botox units
• Drawbacks: Not suitable for small areas or patients with an allergy to lactose or cow's milk protein

XEOMIN®

• Benefits: Ideal for patients who have stopped responding to Botox® or Dysport®
• Onset: 5-7 days
• Results: 3-4 months
• Average Units: 20 units for forehead treatment
• Drawbacks: Longer onset time

JEUVEAU®

• Benefits: Jeuveau® is the same molecule as Botox® only smaller, leading to faster onset. Botox®track record proves that it is clinically safe. Our personal favorite. 
• Onset: 2 -3 days
• Results: 3-4 months
• Average Units: 20 units for forehead treatment 
• Drawbacks: Has not recieved the same recognition as Botox - likely marketing being newer

What to Expect?

• Some patients may experience temporary bruising or tenderness at the treated site.
• The injections are a simple and quick procedure that can be done easily during a lunch hour or between other appointments.
• Depending on the number of sites being treated, treatment may last between 5-10 minutes. 
• No Downtime!
• Results begin to shown in 2-5 days with full effects shown by 2 weeks. 
• Longevity of results last between 3-6 months, with most lasting around 3-4 months.

At Truth, Popular Treatments Include:

• Forehead Wrinkles
• Frown Lines “11’s”
• Crow's Feet
• Brow Lift
• Bunny Lines
• Jelly Rolls under Eyes
• Gummy Smile
• Lip Flip
• DAO (Downward Turn of the mouth)
• Dimpled Chin (Orange peel chin)
• Underarms for Excessive Sweating (Hyperhydrosis)
• Masseter Muscles for TMJ Relief and Facial Slimming
• Platysma Muscle (Neck) to Smooth Hanging Bands or Horizontal Neck Creases